Fructose malabsorption, also known as dietary fructose intolerance, is a digestive disorder in which the small intestine is unable to properly absorb fructose, a type of sugar found in many fruits, vegetables, and sweeteners. Fructose is normally absorbed in the small intestine and then transported into the bloodstream, but in individuals with fructose malabsorption, the fructose passes through to the colon, where it ferments and produces gas, causing various symptoms.

Fructose malabsorption is typically caused by a deficiency of the protein called GLUT5, which is responsible for transporting fructose across the intestinal wall. Without enough GLUT5, fructose accumulates in the intestine and can cause symptoms such as abdominal pain, bloating, gas, diarrhoea, and sometimes nausea.

Fructose malabsorption is different from hereditary fructose intolerance (HFI), which is a rare and more severe genetic disorder caused by a deficiency of the enzyme aldolase B, involved in fructose metabolism. HFI can lead to serious health consequences if fructose is ingested, including liver and kidney damage, whereas fructose malabsorption is generally considered to be a milder condition.

Treatment for fructose malabsorption usually involves avoiding or limiting the intake of fructose and fructose-containing foods in the diet. A low-fructose diet, which may involve avoiding high-fructose fruits, certain vegetables, and added sugars with high fructose content, is often recommended.

If you suspect you may have an issue with fructose malabsorption, please book in to chat with me about your specific symptoms and possible testing & treatment.

Fructose Malabsorption

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